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KMID : 1059519850290040341
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Journal of the Korean Chemical Society
1985 Volume.29 No. 4 p.341 ~ p.347
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A Measure of Chemical Carcinogenic Activity for Metal Ions
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Park Byung-Kak
Yeo Hwhan-Jin
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Abstract
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Formation of metal complex is the first step in the many biological actions of metal ions present in the biological systems. In this work the not electron affinity necessary for the formation of such metal complexes has been determined for a series of metal ions. It has been found that excess polarizing strength can be adopted as a measure of electron affinity and trend is the excess polarizing strength is related to Irving-Williams series. Those metal ions having greater than 0.22 in value of excess polarizing strength have been found to show carcinogenicity and other metal ions, which are supposed to be carcinogenic, have shows to have greater than 0. 22 in value of excess polarizing strength, demonstrating that excess polarizing strength could be used to determine if any metal ion possesses carcinogenic activity.
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